Figure 5.

Disruption of hair follicle development in the skin of Cutl1 mutant mice. (A–D) Histological analysis of the skin from wild-type and Cutl1^Z/Z mice at E18.5 (A,B) and postnatal day 21 (C,D), respectively. (E) β-Galactosidase staining of a skin section from a 20-day-old Cutl1^Z/Z mouse. (F) Higher magnification of an X-gal-stained Cutl1^Z/Z hair follicle that grew parallel to the epidermal surface. Cutl1 mutant survivors on the C57BL/6 × 129/Sv background were analyzed. (DP) Dermal papilla; (HS) hair shaft; (IRS) inner root sheath; (Ma) matrix; (ORS) outer root sheath.