Table 3.
Parameters of lipid metabolism of Wilson disease patients under therapy.
| n | Limits of normal | Hepatic | Neurological | Mixed | Asymptomatic | p-value | |
| ALT | 249 | f: -35 U/l m: -50 U/l |
41 (10-3743) |
25 (11-70) |
30 (13-99) |
24.5 (8-78) |
<0.001 |
| AST | 250 | f: -35 U/l m: -50 U/l |
29 (12-2106) |
23 (10-102) |
27.9 (12-79) |
20 (11-77) |
<0.001 |
| Bilirubin | 239 | < 1.0 mg/dl |
0.7 (0.2-23.0) |
0.6 (0.2-2.7) |
0.7 (0.2-4.5) |
0.6 (0.3-1.9) |
0.001 |
| Albumin | 231 | 30-50 g/l | 44 (21-55) |
44.4 (28-56) |
44 (30-73) |
45.6 (37-54) |
0.277 |
| TG | 247 | < 150 mg/dl | 100 (28-888) |
95 (29-438) |
106.5 (12-221) |
93 (29-285) |
0.588 |
| Cholesterol | 248 | < 200 mg/dl | 179.5 (90-319) |
182 (120-365) |
183 (113-273) |
188.5 (103-265) |
0.780 |
| HDL | 124 | >50 mg/dl | 55 (27-113) |
53 (32-103) |
57.5 (40-81) |
57 (36-84) |
0.588 |
| LDL | 115 | < 160 mg/dl | 108 (43-218) |
96 (63-229) |
98.5 (63-159) |
113.5 (74-156) |
0.781 |
| Lp(a) | 61 | < 25 mg/dl |
4.8 (5-52.5) |
21.4 (4.8-48.5) |
4.9 (4.8-55.4) |
20.5 (4.8-38.9) |
0.016 |
| BMI | 166 | 18.5-25 kg/m² | 22.8 (14.2-41.1) |
22.1 (17.7-33.7) |
23.8 (15.1-32.5) |
22.1 (18.7-28.1) |
0.839 |
With improvement of liver function, parameters of lipid metabolism were comparable between patients, independent of initial presentation.