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. 2011 May 25;6:26. doi: 10.1186/1749-8104-6-26

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Copyright ©2011 Ori-McKenney and Vallee; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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BrdU birthdating study reveals defects in neuronal migration in the Loa/Loa mutants. (A,B) Pregnant mice were injected with BrdU at either E16 (A) or E18 (B), and wild-type and Loa/Loa littermates were sacrificed at P0. (A) Migration of E16 BrdU-labeled neurons in wild-type and Loa/Loa brain slices reveals a delay in migration for the Loa/Loa neurons, which is quantified in the graph below (mean density of BrdU-positive cells ± standard deviation). (B) Migration of E18 BrdU-labeled neurons in wild-type and Loa/Loa brain slices reveals a delay in migration for the Loa/Loa neurons, which is quantified in the graph below (mean density of BrdU-positive cells ± standard deviation). Scale bar = 200 μm.