Table 1.
Summary of demographic data and pertinent neuropathologic findings. Abbreviations: S1–S18 = brains of demented patients with severe cerebral amyloid angiopathy; M1–M21 = brains of demented patients with mild cerebral amyloid angiopathy; F = female; M = male; NA = not available; AD = Alzheimer's disease classified according to the Consortium to Establish a Registry for Alzheimer's Disease into definite (def), probable (prob) and possible (poss); VD = vascular dementia; HS = hippocampal sclerosis (B = bilateral, L = left, R = right); DLBD = diffuse Lewy body disease; B & B = Braak and Braak neurofibrillary tangle stage; CAA = severity of cerebral amyloid angiopathy graded in accordance with the Vonsattel criteria; N = number of; GM = gray matter; WM = white matter; Art‐S = subcortical arteriosclerosis; Ath‐S = basal brain atherosclerosis.
| Case | Age‐sex* | Brain weight (g) | Dementing diseases | B & B stage | CAA grade | N blocks | N microinfarct | Aver N† microinfarct | Art‐S‡ | Ath‐S§ | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GM | WM | GM | WM | |||||||||
| S1 | 93‐F | 1030 | Prob AD | IV | III | 17 | 0 | 1 | 0 | 0.06 | 0 | 3 |
| S2 | 91‐M | 1250 | VD/Poss AD/B‐HS | IV–V | III | 14 | 2 | 0 | 0.14 | 0 | 1 | 2 |
| S3 | 81‐F | 1030 | Def AD | V–VI | III | 16 | 0 | 0 | 0 | 0 | 0 | 2 |
| S4 | 75‐F | 1000 | Def AD | VI | III | 14 | 1 | 0 | 0.07 | 0 | 1 | 1 |
| S5 | 80‐M | 1450 | Prob AD | V–VI | III | 14 | 0 | 0 | 0 | 0 | 2 | 1 |
| S6 | 83‐M | 1420 | Def AD | V | III | 18 | 1 | 0 | 0.06 | 0 | 0 | 2 |
| S7 | 69‐M | 1110 | Def AD | VI | III | 17 | 1 | 3 | 0.06 | 0.18 | 0 | 1 |
| S8 | 86‐F | NA | Def AD | VI | III | 15 | 0 | 0 | 0 | 0 | 3 | 1 |
| S9 | 77‐M | 1240 | Def AD | IV | III | 16 | 9 | 10 | 0.56 | 0.63 | 3 | 2 |
| S10 | 90‐M | 1110 | Def AD | V | III | 18 | 0 | 1 | 0 | 0.06 | 1 | 1 |
| S11 | 80‐M | 1110 | VD/Prob AD/B‐HS | IV | III | 16 | 4 | 0 | 0.25 | 0 | 3 | 2 |
| S12 | 85‐F | 1170 | Def AD | VI | III | 16 | 2 | 0 | 0.13 | 0 | 2 | 1 |
| S13 | 75‐M | 1110 | VD/Def AD | IV | III | 19 | 32 | 5 | 1.68 | 0.26 | 3 | 1 |
| S14 | 87‐M | 1360 | Def AD | VI | III | 17 | 5 | 0 | 0.29 | 0 | 0 | 2 |
| S15 | 74‐F | 950 | Def AD | VI | III | 18 | 0 | 0 | 0 | 0 | 3 | 3 |
| S16 | 97‐F | 920 | Def AD | VI | III | 17 | 0 | 2 | 0 | 0.12 | 0 | 3 |
| S17 | 62‐M | 1450 | Prob AD | III–IV | III | 18 | 0 | 1 | 0 | 0.06 | 0 | 1 |
| S18 | 96‐F | 890 | Def AD/L‐HS | VI | III | 16 | 4 | 2 | 0.25 | 0.13 | 3 | 3 |
| M1 | 78‐M | 1360 | Prob AD | VI | I | 15 | 0 | 0 | 0 | 0 | 0 | 3 |
| M2 | 74‐M | 1160 | Def AD | VI | I | 15 | 0 | 0 | 0 | 0 | 1 | 1 |
| M3 | 76‐M | 1250 | DLBD/Prob AD | V–VI | I | 15 | 0 | 0 | 0 | 0 | 0 | 1 |
| M4 | 89‐M | 940 | Prob AD/L‐HS | VI | I | 13 | 1 | 0 | 0.08 | 0 | 1 | 3 |
| M5 | 86‐M | 940 | Def AD | VI | I | 18 | 0 | 0 | 0 | 0 | 0 | 1 |
| M6 | 90‐M | 1110 | Def AD/R‐HS | VI | I | 18 | 0 | 3 | 0 | 0.17 | 0 | 2 |
| M7 | 86‐F | 1130 | Def AD | V–VI | I | 17 | 0 | 0 | 0 | 0 | 2 | 2 |
| M8 | 72‐F | 950 | Def AD | VI | I | 18 | 0 | 0 | 0 | 0 | 0 | 2 |
| M9 | 86‐F | 1250 | Def AD | V | I | 18 | 0 | 1 | 0 | 0.06 | 1 | 1 |
| M10 | 85‐F | 1050 | Def AD | VI | I | 17 | 0 | 0 | 0 | 0 | 0 | 1 |
| M11 | 79‐M | 1320 | Poss AD | III–IV | I | 19 | 0 | 0 | 0 | 0 | 1 | 2 |
| M12 | 87‐M | 1170 | Def AD | V | I | 17 | 2 | 4 | 0.12 | 0.24 | 3 | 1 |
| M13 | 88‐F | 1070 | Prob AD | IV | I | 16 | 1 | 0 | 0.06 | 0 | 2 | 2 |
| M14 | 81‐M | 1100 | Def AD | VI | I | 14 | 0 | 0 | 0 | 0 | 0 | 2 |
| M15 | 69‐F | 910 | Def AD | VI | I | 18 | 0 | 4 | 0 | 0.22 | 1 | 1 |
| M16 | 76‐F | 1070 | Def AD | VI | I | 18 | 0 | 0 | 0 | 0 | 1 | 1 |
| M17 | 89‐M | 1165 | Def AD | VI | I | 18 | 0 | 0 | 0 | 0 | 2 | 2 |
| M18 | 101‐F | 960 | Def AD | VI | I | 17 | 0 | 0 | 0 | 0 | 2 | 2 |
| M19 | 95‐M | 1240 | Prob AD | V–VI | I | 16 | 2 | 0 | 0.13 | 0 | 3 | 1 |
| M20 | 88‐F | 1100 | Def AD | VI | I | 15 | 0 | 0 | 0 | 0 | 1 | 3 |
| M21 | 89‐F | 860 | Def AD | VI | I | 18 | 0 | 0 | 0 | 0 | 1 | 1 |
Age in years.
The average number of old microinfarcts across brain regions.
Degree of subcortical arteriosclerosis: 0 = absent, 1 = mild, 2 = moderate, 3 = severe.
Degree of basal brain atherosclerosis: 1 = mild, 2 = moderate, 3 = severe.