Table 2.
Additional coexistent brain autopsy findings. Abbreviations: S1–S18 = brains of demented patients with severe cerebral amyloid angiopathy; M1–M21 = brains of demented patients with mild cerebral amyloid angiopathy; PMD = postmortem delay; d = days; h = hours; NA = not available; R = right; L = left; WM = white matter; GM = gray matter.
| Case | PMD | Additional coexistent brain autopsy findings |
|---|---|---|
| S1 | 3 d | Purkinje cell loss in superior cerebellar vermis |
| S2 | NA | WM pallor |
| S3 | NA | Early Parkinson's disease changes |
| S4 | 7 h | None |
| S5 | 2 d | Acute microhemorrhage in R parietal and L temporal cortex |
| S6 | 5 h | Periventricular WM rarefaction; Focal Purkinje cell loss |
| S7 | 2 d | Neuronal loss in substantia nigra and locus ceruleus (clinical parkinsonism) |
| S8 | 12 h | Old microinfarct in thalamus; Periventricular WM rarefaction |
| S9 | 2 d | WM rarefaction; Calcific vasculopathy |
| S10 | 3 d | Neuronal loss in L prosubiculum |
| S11 | 1 d | Subcortical WM rarefaction/gliosis; Neuronal loss in substantia nigra; Calcific vasculopathy |
| S12 | 4 d | None |
| S13 | 1 d | Old microinfarct in basal ganglia |
| S14 | 3 d | Parkinson's disease |
| S15 | 14 h | WM pallor/astrocytosis; Acute/subacute large WM infarct in L parietal and R/L occipital lobes |
| S16 | 12 h | WM pallor; Old microhemorrhage in R amygdala |
| S17 | NA | None |
| S18 | 4 h | Old microinfarct in L basal ganglia; Cavernous angioma at midbrain‐pons junction |
| M1 | 4 h | Focal Purkinje cell loss |
| M2 | 8 h | R hippocampal glial scar |
| M3 | 6 h | None |
| M4 | 2 d | None |
| M5 | 12 h | None |
| M6 | 1 d | None |
| M7 | 5 d | Periventricular WM rarefaction/gliosis; Focal Purkinje cell loss; Meningioma at falx cerebri |
| M8 | 1 d | WM rarefaction/perivascular gliosis |
| M9 | 2 d | Metastatic small‐cell lung carcinoma in R occipital pole |
| M10 | 1 d | None |
| M11 | 2 d | Multifocal astrogliosis in R/L hippocampal formations, R basal ganglia, R temporal pole, and R cingulate gyrus |
| M12 | 1 d | Rare Lewy bodies in locus ceruleus |
| M13 | 5 d | Rare Lewy bodies in locus ceruleus |
| M14 | 22 h | WM pallor/gliosis; Neuronal loss in locus ceruleus |
| M15 | 15 h | WM pallor/astrocytosis; Neuronal loss in locus ceruleus |
| M16 | 21 h | WM pallor |
| M17 | 15 h | Multifocal microglial proliferation in R/L cerebral WM; Acute microinfarct in cerebellar GM |
| M18 | 1 d | Focal Purkinje cell loss |
| M19 | 22 h | Old hemorrhagic microinfarct in midbrain |
| M20 | 3 d | WM pallor; Fourth ventricular subependymoma; R vestibular schwannoma |
| M21 | 4 h | Calcific vasculopathy in basal ganglia |