Table 2. MTF-1 target genes obtained in the screenings (established and putative).
| Gene |
Source of evidence |
MRE in regulatory regiona |
Binding of MTF-1 to oligob |
| Stress-responsive genes | |||
| MT-II | Detailed in vivo and in vitro evidence (4,16; E13.0 microarray) | 6 MREs in promoter (M) | ++++ |
| AFP | SABRE, E13.0/E12.5 microarray | 5 MREs in promoter/enhancers (R) | +++ |
| Glucose 6-phosphate dehydrogenase | Database search | 5 MREs in promoter (H) | |
| Transforming growth factor β-1 | Database search | 3 MREs in promoter (M) | |
| Cytosolic zinc-binding protein | Database search | 1 MRE in promoter (R) | |
| Tear lipocalin | Cell culture data and in vitro evidence | 5 MREs in promoter (H) | +++ |
| AMD-1 S-adenosylmethionine decarboxylase | Database search | 6 MREs in promoter (M) | |
| BiP (hsp 70 family) | SABRE | Noc | |
| Vacuolar adenosine triphosphatase subunit b | E12.5 microarray | Missing sequence information | |
| Secretory liver proteins | |||
| Fetuin | E13.0 microarray | 3 MREs in promoter (M) | |
| Corticoid-binding globulin | E13.0 microarray | 1 MRE in promoter (M) | |
| Plasma retinol-binding protein | E13.0 microarray | Noc | |
| Liver-enriched transcription factors | |||
| HNF-3α | Database search | 3 MREs in promoter (M) | |
| HNF-3γ | Database search | 5 MREs in promoter (R) | |
| Hfh-1L | Database search | 8 MREs in promoter (M) | |
| C/EBPα | Database search | 5 MREs in 5′-upstream region (R) | +++ |
| Signal pathway factors | |||
| ALK-6 (TGFβ receptor type I) | E13 microarray | Missing sequence information | |
| Inhibin/activin bc subunit | Database search | 1 MRE in promoter (M) | |
| FGF receptor | E13 microarray | Missing sequence information | |
| Gas3/PMP22 | E13 microarray | 2 MREs in promoter (M) | |
| Notch-1 | Database search | 3 MREs in promoter (M) | |
| Tissue-specific proteins | |||
| SV2 | SABRE | Missing sequence information | |
| Neuronal nicotinic acetylcholine receptor | Database search | 4 MREs in promoter (M) | |
| Dopamine receptor D1 | Database search | 1 MRE (R) | |
| Testes-specific kinase 1 | Database search | 6 MREs in promoter (M) | |
| Synaptonemal complex protein I | Database search | 3 MREs in promoter (M) | |
| Other transcripts | |||
| XIST | SABRE | 3 MREs in promoter (M) | |
| ESTs | |||
| ms20h07 | E13.0 microarray | Missing sequence information | |
| mg75d07 | E13.0 microarray | Missing sequence information | |
| mq10d02 | E13.0 microarray | Missing sequence information | |
| va1e02 | E13.0 microarray | Missing sequence information | |
| vk53c08 | E13.0 microarray | Missing sequence information | |
| vn65b01 | E13.0 microarray | Missing sequence information | |
| vl04h06 | E13.0 microarray | Missing sequence information | |
| C76222 | E13.0 microarray | Missing sequence information | |
| Genes transcriptionally up-regulated in MTF-1 knockout embryos/livers | |||
| Cell division control protein 3 | E13.0 microarray | Missing sequence information | |
| NF-YB transcription factor | E13.0 microarray | Noc | |
| Activin receptor II(B) | E13.0 microarray | 7 MREs in upstream region (–1.8 kb) (H) | |
| Hepatopoietin receptor (ERV1) | E12.5 microarray | Missing sequence information | |
a(M), mouse; (H), human; (R), rat. Human or rat were considered when mouse sequence was unavailable.
bMREs were tested only from the indicated subset of genes.
cA remote cis-regulatory region with MREs cannot be excluded. Alternatively, indirect transcriptional regulation via MTF-1 is possible.