Table 3. MTF-1 target genes described in the literature.
Gene |
Source of evidence |
MRE in regulatory regiona |
Binding of MTF-1 to oligob |
Stress-responsive genes | |||
MT-I | Detailed in vivo and in vitro evidence (4,16) | 6 MREs in promoter (M) | ++++ |
ZnT-1 | Detailed in vivo and in vitro evidence (59) | 3 MREs in promoter (M) | |
γ-GCS | Conflicting in vivo data, but promoter responsive to MTF-1 in transient transfections (16) | 1 MRE in promoter, 1 in leader (H) | +/+++ |
γ-Glutamyltranspeptidase | Database search (16) | 3 MREs in promoter (M) | |
PlGF | In vivo and in vitro evidence (60) | 2 MREs in promoter (M) |
a(M), mouse; (H), human. Human was considered when mouse sequence was unavailable.
bMREs were tested only from the indicated subset of genes.