Table 2. Over-represented gene ontology categories of the up-regulated genes in MG132 treated RIF-1 cells.
GO ID | Term description | Population count | Study count | Adjusted |
P-values | ||||
Biological Process | ||||
GO:0008152 | metabolic process* | 5252 | 410 | 0.000 |
GO:0023034 | intracellular signaling pathway* | 682 | 41 | 0.000 |
GO:0007242 | intracellular signaling cascade* | 920 | 60 | 0.000 |
GO:0051239 | regulation of multicellular organismal process | 842 | 63 | 0.000 |
GO:0006950 | response to stress | 1083 | 109 | 0.000 |
GO:0048519 | negative regulation of biological process | 1277 | 104 | 0.000 |
GO:0016265 | death* | 809 | 81 | 0.000 |
GO:0001816 | cytokine production | 143 | 19 | 0.000 |
GO:0009987 | cellular process | 8567 | 547 | 0.003 |
GO:0009056 | catabolic process | 603 | 74 | 0.005 |
Cellular Component | ||||
GO:0005622 | intracellular* | 7149 | 606 | 0.000 |
GO:0043226 | organelle* | 5933 | 484 | 0.000 |
GO:0005623 | cell | 10521 | 684 | 0.000 |
GO:0000502 | proteasome complex | 53 | 19 | 0.000 |
GO:0032991 | macromolecular complex | 1977 | 164 | 0.000 |
GO:0042611 | MHC protein complex | 26 | 7 | 0.007 |
GO:0005625 | soluble fraction | 258 | 34 | 0.007 |
Molecular Function | ||||
GO:0005488 | binding* | 7994 | 564 | 0.000 |
GO:0003824 | catalytic activity | 3617 | 289 | 0.000 |
GO:0022890 | inorganic cation transmembrane transporter activity | 107 | 15 | 0.006 |
*Common categories of up-regulated genes in heat shock and MG132 treated RIF-1 cells.