Table 2. Over-represented gene ontology categories of the up-regulated genes in MG132 treated RIF-1 cells.

GO ID	Term description	Population count	Study count	Adjusted
				P-values
Biological Process
GO:0008152	metabolic process*	5252	410	0.000
GO:0023034	intracellular signaling pathway*	682	41	0.000
GO:0007242	intracellular signaling cascade*	920	60	0.000
GO:0051239	regulation of multicellular organismal process	842	63	0.000
GO:0006950	response to stress	1083	109	0.000
GO:0048519	negative regulation of biological process	1277	104	0.000
GO:0016265	death*	809	81	0.000
GO:0001816	cytokine production	143	19	0.000
GO:0009987	cellular process	8567	547	0.003
GO:0009056	catabolic process	603	74	0.005
Cellular Component
GO:0005622	intracellular*	7149	606	0.000
GO:0043226	organelle*	5933	484	0.000
GO:0005623	cell	10521	684	0.000
GO:0000502	proteasome complex	53	19	0.000
GO:0032991	macromolecular complex	1977	164	0.000
GO:0042611	MHC protein complex	26	7	0.007
GO:0005625	soluble fraction	258	34	0.007
Molecular Function
GO:0005488	binding*	7994	564	0.000
GO:0003824	catalytic activity	3617	289	0.000
GO:0022890	inorganic cation transmembrane transporter activity	107	15	0.006

*Common categories of up-regulated genes in heat shock and MG132 treated RIF-1 cells.