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. 2001 Apr 1;29(7):1491–1506. doi: 10.1093/nar/29.7.1491

Figure 4.

Figure 4

Dendrogram of all available sequences of N4 and N6 MTases of the α group. The sequences compared consisted of the N- and C-termini, with the central TRD removed. The TRD was liberally defined as the block corresponding to residues 77 through 172 according to M.DpnII coordinates (15). The branches of all N6mA MTases are some hue of red and of all N4mC MTase some hue of blue. Thin lines indicate that the target sequence of the enzyme has not been established by biochemical criteria. Besides those sequences listed in Table 1, the following were found through the indicated accession nos: M.AvaI (CAA66984), M.BsoBI (CAA66933), M.CviAII (S27901), M.CviBI (Q01511), M.EcDam (P00475), M.EcoRV (P04393), M.EcoT4Dam (X17641), M.FokI (P14871), M.MboIA (P34720), M.MvaI (P14244), M.NcoI (AAC23514), M.NlaIII, M.PspGI (AAC67523), M.SphI (AAB40377) and M.TpaI (AAB82782). M.FokI and M.StsI consist of two separable MTases that are fused as a single polypeptide. The N-terminal portions (M.FokIa and M.StsIa) recognize one asymmetric target and the C-terminal portions (M.FokIb and M.StsIb) recognize the other.