Figure 1.

Drosophila Geminin and comparison with Xenopus and human Geminin. (A) Drosophila (Dm) geminin gene structure showing location of P-element alleles relative to the transcriptional unit. (B) Sequence comparison with Xenopus (Xl) and human (Hs) Geminin. The sequences were aligned using the GCG Gap program. Identical amino acids are marked with a vertical line and conservative changes are indicated (*). Differences between Xl H and L forms are indicated. The putative destruction box is in boldface type. The neuralization domain is underlined and the DNA replication inhibition domain is indicated by the broken underline. The double line above the sequence alignment shows the coiled-coil region. The degree of identity and similarity (in parentheses) between Xl Geminin L, Hs and Dm Geminin sequences is indicated for each domain.