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. 2011 Jun 30;6(6):e21572. doi: 10.1371/journal.pone.0021572

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Magnusson et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The sex-biased genes with transcription values for at least three of the five developmental stages analysed (1^st instar larvae (L1), 2^nd/3^rd instar larvae (L2-3), 4^th instar larvae (L4), pupae (P), adults (A)) are arranged in co expression K-means clusters. The number of genes included in each cluster is indicated in brackets. The clusters are arranged in three groups according to the average sex-bias profile at the adult stage. Group A (M1-M4) and B (F1-F4) contain genes that have distinct developmental transcription profiles but have a male- and female-bias respectively at the adult stage. Group C (E1-E3) contains genes that are sex-biased (either male or female) at early developmental stages but not sex-biased in adult mosquitoes. See also Figure S6 and Tables S4, S7.