Table 4. Sites of parallel, positive and nuclear trafficking signal mouse adapted mutations.
| gene | sites of parallel evolution/mutations (mutants)a | postiveb | total | nuclear traffic signals |
| PB2 | 482(3), 701(27), 740(9) | 6 | 17 | 480, 482, 701, 740 (NLS) |
| PB1 | 577/3(10) | 4 | 8 | 190 (NLS) |
| PB1-F2 | none | none | none | none |
| PA | 21(4), 27(4), 70(4), 97(6), 190/2(5) | 7 | 13 | 190 (NLS) |
| NP | 34(24), 290/2(14) | 7 | 13 | 4 (NLS) |
| HA | HA1:162/2(2), 210(4), 218/2(19) HA2:154/2(2)+156(8) | 13 | 25 | na |
| NA | 110/2(2) | 4 | 19 | na |
| M1 | none | 2 | 3 | ? |
| M2 | none | 1 | 2 | na |
| NS1 | 106/2(6) | 6 | 10 | ? |
| NEP | none | 1 | 5 | 23 (NES) |
| total | 17/27(39) | 51 | 115 | 8 |
a
format - amino acid positions/number of mutations if >1 (number of mutants among 39 MA clones in parentheses).
b
total number of positive and parallel mutations.
NLS, nuclear localization signal.
NES, nuclear export signal.
na, not applicable.