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. 2011 Jun 30;7(6):e1002108. doi: 10.1371/journal.pgen.1002108

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Horizontal axis indicates chromosomal position. Vertical axis indicates −log10 P-values from inverse variance-weighted fixed effects meta-analysis. The red horizontal line indicates the genome-wide significance threshold of P = 2.5×10⁻⁸. Association signals are present at 1q23, 4q13, and 16q22. The P-values for the broad chromosome 1 signal are truncated at 10⁻²⁰. This region spans nearly 90 Mb on both arms of chromosome 1 and results artifactually in two apparently distinct peaks because of the lack of genotyped or imputed SNPs around the centromere.