Table 1. Characteristics of Continental Origins and Genetic Epidemiology Networks (COGENT) African-American discovery GWAS participants (n = 16,388).
| Study | Atherosclerosis Risk in Communities (ARIC) | Coronary Artery Risk Development in Young Adults (CARDIA) | Johns Hopkins Genetic Study of Atherosclerosis Risk (GeneSTAR) | Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) | Health, Aging, and Body Composition (Health ABC) | Jackson Heart Study (JHS) | Women's Health Initiative (WHI) |
| Sample size | 2664 | 943 | 934 | 862 | 898 | 1992 | 8095 |
| Study design | Population-based, unrelated | Population-based, unrelated | Population-based, family | Population-based, unrelated | Population-based, unrelated | Population-based, unrelated | Population-based, unrelated |
| Age, years (SD) | 53.4 (5.8) | 24.4 (3.8) | 45.2 (12.6) | 48.2 (9.0) | 73.4 (2.8) | 50.0 (12.1) | 61.6 (7.0) |
| % Female | 63.2 | 58.7 | 61.6 | 56.0 | 58.8 | 61.2 | 100 |
| WBC (SD) | 5.67 (1.85) | 5.92 (2.00) | 6.00 (1.90) | 6.20 (1.97) | 5.60 (2.00) | 5.68 (1.91) | 6.49 (1.50) |
| Neutrophils (SD) | 2.89 (1.45) | 3.11 (1.57) | NA | 3.485 (1.50) | 5.20 (1.80)* | 3.15 (1.51) | NA |
| Lymphocytes (SD) | 2.17 (0.75) | 2.23 (0.84) | 2.24 (0.71) | 2.08 (0.69) | 1.80 (0.70)* | 1.96 (0.66) | NA |
| Monocytes (SD) | 0.344 (0.197) | 0.314 (0.184) | 0.308 (0.16) | 0.386 (0.148) | 0.400 (0.100)* | 0.390 (0.145) | NA |
| Eosinophils (SD) | 0.165 (0.165) | NA | NA | 0.150 (0.099) | 0.200 (0.100)* | 0.139 (0.126) | NA |
| Basophils (SD) | 0.037 (0.043) | 0.046 (0.044) | NA | 0.026 (0.014) | 0.055 (0.040)* | 0.033 (0.022) | NA |
WBC and sub-type measures are reported in cells ×109/liter [mean(SD)].
SD = standard deviation; NA = not available.
*In HABC, white blood cell sub-types were only available in a subset of participants (n = 207).