Table 2. Results of genome-wide significant SNPs for total white blood cell count.

Chromosome	Number SNPS with P<2.5×10−8	Top SNP in region	Position	Candidate gene	Minor/Major allele	Minor allele frequency	Effect size (Standard Error)	P-value
1q23	>10,000	rs2814778	157441307	DARC	T/C	0.21	+0.230 (0.005)	1.0×10−524
4q13	1	rs9131	75181913	CXCL2	T/C	0.23	−0.023 (0.004)	1.6×10−8
16q22	14	rs12149261	69555646	HYDIN	A/C	0.25	+0.083 (0.005)	3.5×10−75

For each locus, the lead SNP with the smallest P-values among the genotyped or imputed SNPs are indicated. Effect size represents the effect of a minor allele on natural log-transformed white blood cell count. Positions of the SNPs were derived from dbSNP build 136.