Table 3. Meta-analysis results of genome-wide significant SNPs for white blood cell count subtypes.
Cell type | Chromosome 1q23 DARC rs2814778 T allele | Chromosome 4q13 CXCL2 rs9131 T allele | ||||
N | Effect size (Standard Error) | P-value | N | Effect size (Standard Error) | P-value | |
Neutrophils | 5609 | +0.305 (0.009) | 1.0×10−237 | 7353 | −0.038 (0.008) | 1.5×10−6 |
Lymphocytes | 5642 | +0.020 (0.007) | 3.8×10−3 | 7390 | +0.010 (0.005) | 0.06 |
Monocytes | 5593 | +0.048 (0.004) | 6.0×10−27 | 7330 | −0.004 (0.004) | 0.23 |
Eosinophils | 5411 | +0.012 (0.003) | 8.6×10−5 | 6402 | −0.0005 (0.003) | 0.85 |
Basophils | 5104 | +0.002 (0.0008) | 3.5×10−3 | 6052 | −0.0007 (0.0007) | 0.27 |
Effect size represents the effect of a minor allele on natural log-transformed white blood cell count.