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. 2011 Jun 30;7(6):e1002153. doi: 10.1371/journal.pgen.1002153

Figure 1. Dynamic relocalization of Sirt6 genome-wide upon stress-signaling.

Figure 1

(A) Endogenous Sirt6 targets the promoter of 5050 genes in the presence or absence of TNF-α. The heatmap displays the binding data as the degree of enrichment of ChIP DNA over total genomic DNA. (B) Shown are the gene ontologies (GO) terms significantly induced (pval<.05, Benjamini) among Sirt6 targets in wild-type MEFs following treatment with TNF-α. Intensity of orange is representative of the degree of significance. (C) Shown are the motif modules significantly induced (pval<.05) among Sirt6 targets in wild-type MEFs following treatment with TNF-α. Intensity of purple is representative of the degree of significance [-ln(pval)].