Skip to main content
. 2011 Jun 30;7(6):e1002153. doi: 10.1371/journal.pgen.1002153

Figure 3. RelA drives dynamic relocalization of Sirt6.

Figure 3

(A) Example of ChIP-chip data for Sirt6 and RelA show substantial similarity. (B) Venn diagram representing the overlap of Sirt6 and RelA promoter bound regions. (C) RelA and Sirt6 bind shared targets within 500 bp of each other. The distance between RelA and Sirt6 binding sites and the percentage of shared targets with the corresponding distance is plotted. (D) Sirt6 occupancy at promoters shared by RelA is largely dependent on RelA. Shown is a heat map displaying the ChIP binding data in wild-type and RelA−/− MEFs following TNF-α treatment for the indicated times, for 1481 gene promoters shared by RelA and Sirt6. The average binding of Sirt6 for each sample (column) is plotted above. The grey bar indicates that Sirt6 binding is completely abrogated in RelA−/− samples. 49% of shared Sirt6 targets are dependent on RelA.