Table 4. Meta-analysis of GWAS–identified Triglyceride SNPs.
| SNP | Nearest Gene | CA | European Americans(nmax = 24,258) | African Americans(nmax = 9,844) | American Indians(nmax = 6,157) | Mexican Americans and Hispanics(nmax = 2,973) | G | ||||||||
| CAF | β (SE) | P-value | CAF | β (SE) | P-value | CAF | β (SE) | P-value | CAF | β (SE) | P-value | ||||
| rs1748195 | ANGPTL3 | C | 0.66 | 0.03 (0.01) | 1.93E-07 | 0.35 | 0.01 (0.01) | 0.19 | 0.61 | 0.16 (0.07) | 2.44E-02 | 0.60 | 0.04 (0.01) | 1.17E-02 | N |
| rs1260326 | GCKR | T | 0.42 | 0.05 (0.01) | 6.44E-13 | 0.16 | 0.05 (0.02) | 9.98E-04 | 0.28 | 0.15 (0.09) | 8.52E-02 | 0.33 | 0.06 (0.02) | 1.97E-04 | N |
| rs780094 | GCKR | A | 0.40 | 0.06 (0.01) | 1.69E-32 | 0.18 | 0.02 (0.01) | 2.91E-02 | 0.25 | 0.04 (0.01) | 3.23E-03 | 0.33 | 0.06 (0.02) | 1.13E-03 | Y |
| rs17145738 | MLXIPL | T | 0.12 | -0.07 (0.01) | 5.71E-24 | 0.09 | -0.03 (0.01) | 2.53E-02 | 0.08 | −0.07 (0.02) | 2.30E-04 | 0.07 | −0.09 (0.03) | 7.40E-04 | Y |
| rs328 | LPL | C | 0.90 | 0.09 (0.01) | 4.16E-30 | 0.93 | 0.08 (0.02) | 2.62E-08 | 0.97 | 0.09 (0.03) | 4.83E-03 | 0.93 | 0.09 (0.03) | 6.31E-04 | Y |
| rs2197089 | LPL | T | 0.55 | -0.03 (0.01) | 4.97E-15 | 0.78 | −0.01 (0.01) | 7.45E-02 | 0.41 | −0.05 (0.01) | 2.57E-06 | 0.48 | −0.05 (0.01) | 4.01E-04 | N |
| rs2954029 | TRIB1 | A | 0.54 | 0.05 (0.01) | 1.13E-04 | 0.68 | -0.01 (0.02) | 0.46 | – | – | – | 0.62 | 0.06 (0.02) | 9.28E-04 | N |
| rs174547 | FADS1 | T | 0.66 | −0.03 (0.01) | 3.82E-10 | 0.91 | −0.05 (0.01) | 3.73E-04 | 0.21 | −0.06 (0.02) | 1.10E-04 | 0.39 | −0.05 (0.02) | 1.51E-03 | Y |
| rs28927680 | APOA1/C3/A4/A5gene cluster | C | 0.93 | −0.12 (0.01) | 2.88E-38 | 0.84 | <0.001 (0.01) | 0.95 | 0.83 | −0.13 (0.01) | 6.33E-19 | 0.86 | −0.08 (0.02) | 2.15E-05 | N |
| rs964184 | APOA1/C3/A4/A5gene cluster | G | 0.86 | −0.14 (0.01) | 1.91E-59 | 0.80 | −0.02 (0.01) | 4.87E-02 | 0.78 | −0.17 (0.07) | 1.43E-02 | 0.72 | −0.14 (0.02) | 1.04E-19 | Y |
| rs3135506 | APOA1/C3/A4/A5gene cluster | C | 0.06 | 0.13 (0.01) | 2.59E-33 | 0.06 | 0.11 (0.02) | 2.06E-10 | 0.17 | 0.13 (0.01) | 4.28E-20 | 0.14 | 0.13 (0.02) | 3.08E-08 | Y |
| rs4775041 | LIPC | C | 0.29 | 0.01 (0.01) | 3.15E-02 | 0.14 | 0.03 (0.01) | 4.29E-03 | 0.21 | 0.02 (0.01) | 5.15E-02 | 0.18 | 0.01 (0.02) | 0.58 | N |
| rs16996148 | CILP2/PBX4/NCAN | T | 0.08 | −0.04 (0.01) | 3.91E-05 | 0.15 | <0.001 (0.01) | 0.77 | 0.04 | −0.07 (0.03) | 8.86E-03 | 0.06 | −0.06 (0.03) | 2.69E-02 | N |
| rs7679 | PLTP | T | 0.82 | −0.02 (0.01) | 2.84E-02 | 0.96 | −0.01 (0.02) | 0.61 | 0.94 | −2.0E-03 (0.02) | 0.93 | 0.89 | −0.03 (0.03) | 0.31 | N |
Coded allele (CA); coded allele frequency (CAF); beta coefficient (β); standard error (SE); data not available (–); generalized (G); yes (Y); no (N). Generalization is defined here as a significant association (p<0.05) and a similar direction of effect (β) compared with European Americans for the same test of association, across all racial/ethnic populations.