Table 5. Observed versus expected number of significant associations, by trait and population.

Trait	Race/Ethnicity	# of Total Tests of Association*	# of Observed Significant Associations	# of Expected Significant Associations†	P-value‡
HDL-C	AA	23	11	17.3	0.01
	AI	20	9	14.4	0.01
	MA/H	23	13	13.8	0.83
LDL-C	AA	18	11	14.7	0.03
	AI	14	10	11.9	0.15
	MA/H	18	10	10.6	0.81
ln(TG)	AA	14	8	11.9	0.01
	AI	13	10	8.4	0.56
	MA/H	14	12	10.4	0.54

The expected number of significant associations was based on power calculations assuming an additive genetic model and liberal significance threshold (0.05) in each racial/ethnic group for each test of association. We further assumed the observed genetic effect size (beta) from PAGE European Americans and the observed allele frequency, sample sizes, and trait mean/standard deviations from each non-European American population.

*Only includes associations that replicated in EA.

†Based on the additive power of all loci.

‡One-sample binomial test.

African Americans (AA); American Indians (AI); Mexican Americans/Hispanics (MA/H); number (#).