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In the CB, ERα modulates Calb1 mRNA in both sexes, but sex chromosome genes modulate the sexual dimorphism. Mean + SEM Calb1 in the CB of WT and ERαKO (KO) mice (a) and FCG mice (b). n = 5–6 mice per group. * Females had significantly greater concentrations of Calb1 mRNA than did males (p < 0.015). ** WT littermates had significantly more Calb1 mRNA than did ERαKO mice (p < 0.007). *** XX mice had significantly more Calb1 than did XY mice (p < 0.0001).
