Table 4.
Relative mRNA expression of estrogen receptors Esr1 and Esr2 as a function of sex in the CB and FC
| CB |
FC |
Controls |
||||
|---|---|---|---|---|---|---|
| females | males | females | males | testes | ovaries | |
| Esrl | 0.74 ± 0.19a | 1.59 ± 0.38a | 3.68 ± 1.00a | 4.33 ± 0.78a | 22.13 | 127.85 |
| Esr2 | 0.15 ± 0.04 | 0.15 ± 0.03 | 0.49 ± 0.13 | 0.47 ± 0.06 | 1.00 | 457.00 |
Mean (±SEM) of the relative gene expression of Esr1 and Esr2 mRNA in the CB and FC. n = 5–10 mice per brain region. Estrogen receptor expression was also examined in the testes and ovaries to serve as positive controls. All expression values were normalized to Esr2 in testes.
a
Esr1 expression was significantly greater than Esr2 expression in both the CB (p < 0.002) and the FC (p < 0.0001). No significant differences in Esr1 or Esr2 expression were noted between the sexes.