Table 3.

Correlation between brain and spinal cord MRI data

	Spinal cord MRI measures:
	Volume measures*								Lesion measures
	C2–C3		Cervical		Thoracic		Whole cord		Cervical		Thoracic		Whole cord
Brain MRI measures:	r	p	r	p	r	p	r	p	r	p	r	p	r	p
GMF^	0.307	0.189	0.302	0.196	0.234	0.320	0.229	0.331	−0.119	0.618	0.009	0.971	−0.104	0.661
WMF^	0.323	0.164	0.359	0.120	0.229	0.331	0.272	0.245	0.226	0.339	0.097	0.683	0.258	0.273
BPF^	0.365	0.113	0.375	0.103	0.272	0.245	0.285	0.224	−0.008	0.972	0.044	0.854	0.015	0.950
FLLV	0.092	0.699	0.062	0.794	0.035	0.883	0.098	0.682	0.085	0.720	0.443	0.050	0.307	0.188

Note: GMF=brain gray matter fraction; WMF= brain white matter fraction; BPF= global brain parenchymal fraction; FLLV=Brain fluid-attenuated inversion-recovery hyperintense lesion volume;

^*spinal cord volumes are normalized by number of slices and intracranial volume (see Methods section).

^{^}brain volumes are normalized by intracranial volume (see Methods section)