Table 4.

Correlation between MRI measures and disability (n=21)

	Volume measures														Lesion measures
	Spinal cord*						Brain^								Brain		Spinal cord
	C2–C3 cord volume*		Cervical cord volume		Thoracic cord volume		Whole cord volume		BPF		GMF		WMF		FLLV		Cervical cord T2LV		Thoracic cord T2LV		Whole cord T2LV
	r	p	r	p	r	p	r	p	r	p	r	p	r	p	r	p	r	p	r	p	r	p
EDSS	−0.515	0.020**	−0.436	0.055	−0.224	0.343	−0.258	0.273	0.330	0.155	−0.295	0.207	0.255	0.277	−0.069	0.773	−0.173	0.465	−0.326	0.161	0.199	0.400
T25FW	−0.257	0.274	−0.180	0.449	−0.23	0.924	−0.094	0.694	0.116	0.626	−0.012	0.960	0.282	0.229	−0.440	0.052	−0.048	0.840	0.164	0.488	−0.019	0.937

Note: EDSS = Expanded Disability Status Scale; T25FW= timed 25-foot walk; FLLV=brain fluid-attenuated inversion-recovery hyperintense lesion volume; BPF=global brain parenchymal fraction; GMF=brain gray matter fraction; WMF=brain white matter fraction; T2LV=T2 hyperintense lesion volume;

^*spinal cord volumes are normalized by number of slices and intracranial volume (see Methods section);

^{^}brain volumes are normalized by intracranial volume (see Methods section);

^**p<0.05