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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Exp Eye Res. 2010 Sep 16;93(2):120–132. doi: 10.1016/j.exer.2010.09.005

Figure 4. Hayreh (Hayreh et al., 1970) demonstrated sensitivity of the peripapillary choroidal circulation (green) to acute IOP elevation in the monkey ONH.

Figure 4

Fluorescence fundus angiogram of the right eye of a cynomologus monkey after experimental central retinal artery occlusion at normal (A) and 70 mm Hg IOP (B and C). The non perfused region of the peripapillary choroid is highlighted in green in (C). We and others have hypothesized that IOP-related stress and strain within the scleral flange (Figure 3) may contribute to this phenomenon and that similar effects may occur within the laminar capillary beds (red) (C and D). Panels A and B are reproduced with permission from the British Journal of Ophthalmology (Hayreh et al., 1970). (Panel D reprinted with permission from The Glaucomas. St. Louis: Mosby; 1996:177–97. (Cioffi and Van Buskirk, 1996)