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Overlap in function of the ER-localized Doa10 and Hrd1 ubiquitin ligases. (A) The doa10Δ hrd1Δ double mutant is hypersensitive to cadmium. Congenic cells of the indicated genotypes were spotted in 10-fold dilutions on minimal medium containing CdCl2 or on YPD and incubated for 4 d and 2 d at 30°C, respectively. (B) Induction of the unfolded protein response in a hrd1Δ doa10Δ mutant. Congenic cells carried the plasmid pSZ1, which contains a UPRE–lacZ reporter (Friedlander et al. 2000).
