Age-related incidence (per 100,000 per year) of different cancers among men in the United States is compared with the mortality related to gastric ulcer among men in the UK in 1947 [46]. The cancer data show that adenocarcinoma of the esophagus, despite its marked increase, is a very rare disease with an incidence approximately equal to small bowel cancer. Even after the marked decline in gastric cancer in the US, it remains a much more important problem than adenocarcinoma of the esophagus. Data from the SEER database for the period of 1997–2001 [47]. Clearly the trade-off of loss of gastric cancer and peptic ulcer for higher acid secretion favors eradication. Considering the low prevalence of H. pylori in the high-risk group of White men, all of the effects of H. pylori eradication have likely already occurred. However, effects from diet and obesity will continue to be felt.