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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Future Virol. 2010 May;5(3):313–323. doi: 10.2217/fvl.10.12

Fig. 2. Circular map of the JC virus genome.

Fig. 2

JCV genome is composed of regulatory and coding regions. The regulatory region contains the origin of DNA replication and promoter/enhancer elements. The promoter directs the expression of viral early and late genes and is bidirectional. The early region encodes only the regulatory proteins, LT-Ag, Sm t-Ag and T’ proteins but the late coding region is responsible for the production of a small regulatory agnoprotein and three structural capsid proteins (VP1, VP2, and VP3).