Fig. 1.

Indomethacin induced cellular injury was measured by Tetra-Color One method. The pretreatment of lansoprazole reduced cytotoxicityin a dose-dependent (1, 10, 30 µM) manner and absorbance of Tetra-Color One was significantly higher than those of the un-pretreated group. The viability losses induced by 750 µM indomethacin were 38.7% ± 4.6%. Lansoprazole at 10 and 30 µM significantly inhibited the reduction in cell viability, the inhibition being 14.2% at 10 µM and 14.4% at 30 µM, respectively, as determined by the Tetra Color One assay method. On the other hand, the same amount of pretreatment of omeprazole had no cytoprotective effect in this study. *p<0.05 vs indomethacin 750 µM.