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In this study, we show that copper induces ROS, TNFα and MIP-2 in liver of BALB/c mice and ROS and FasL in HepG2 cells. These effects were reverted by the administration of PPARβ/δ agonist and enhanced by the administration of a PPARβ/δ antagonist. PPARβ/δ’s protective role could be used in clinical settings of liver damage as agonists of this receptor are already being tried in humans.
