Figure 4.

Knowledge processing in biomedicine is based on cycles of formulation—experimentation—interpretation. (A) BIRN's knowledge modeling methodology is based on a generic knowledge model for experimental design (EDlabel>) and specialized models for domain reasoning (DR). (B) We are developing technology to populate this modeling approach from the published literature (using a text mining infrastructure), from online databases (using BIRN's information integration technology) and raw data (using our modeling tools directly within database development systems).