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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Adv Cancer Res. 2011;111:39–96. doi: 10.1016/B978-0-12-385524-4.00002-7

Figure 6. Crystal structures of BHRF1 and Bcl-xL in complex with the Bim BH3 peptide (taken from (Kvansakul et al., 2010)).

Figure 6

A. The structure of BHRF1 (blue) with the helices labeled a1, a1′, a2-8, is shown in complex with the Bim BH3 domain (yellow). The helices a3-5 of BHRF1 form a hydrophobic binding groove into which the BH3 domain of Bim can bind. D. The comparable structure of Bcl-xL (cyan) with helices labeled a1-8 bound to the BH3 domain of Bim (yellow).