Table 3.
Medial joint space width (JSW) and joint space narrowing (JSN) scores in signal knee at baseline and 24 months follow-up in knee OA patients with increased (OAIL-1) versus normal (OAnl) IL-1β expression in entire NYUHJD Validation Cohort and in patients with baseline JSW ≥3 mm.
| Mean (standard deviation) | p-value1 | ||
|---|---|---|---|
| Entire NYUHJD Validation Cohort | OAIL-1 (n=33) | OAnl (n=53) | |
| JSW (mm) at baseline | 3.87 (1.71) | 2.14 (2.15) | 0.0005 |
| JSW (mm) at 24 months | 3.10 (1.79) | 2.01(2.10) | 0.0259 |
| Change (JSN) | 0.77 (0.95) | 0.15 (1.23) | 0.0208 |
| In patients with baseline JSW ≥3 mm | OAIL-1 (n=25) | OAnl (n=28) | |
| JSW (mm) at baseline | 4.67 (0.28) | 4.25 (0.19) | 0.142 |
| JSW (mm) at 24 months | 3.78 (0.35) | 3.86 (0.24) | 0.8203 |
| Change (JSN) | 0.89 (0.26) | 0.38 (0.18) | 0.0507 |