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Schematic overview of comparative glycosaminoglycan compositional profiling of different species simultaneously using tetraplex isotope coded tags. Total GAG chains isolated from different species are digested into disaccharides using lyases and incubated individually with one tetraplex tag each. After labeling with the tetraplex tags and purifying the GAGs, labeled disaccharides from different species are combined into one sample and analyzed simultaneously on the mass spectrometer.
