Figure 4.

Behavior of SNP-A characterized lesions through the clinical course. Using SNP-A–based karyotyping, clonal monosomy 7 was identified earlier in some patients in our cohort (nos. 122, 75, 38). In addition, SNP-A analysis identified clonal lesions in a patient (no. 38) before immunosuppression that disappeared posttreatment. Number 75 had normal cytogenetics by MC at presentation but SNP-A analysis revealed a uniparental disomy (UPD). Black squares indicate clinical time points where karyotyping was performed using SNP-A and/or metaphase cytogenetics. The metaphase karyotype is given above and the SNP-A-based karyotype below the bars representing the clinical course. NG indicates no growth of the metaphase culture; and NA, result not available. Black arrows indicate when immunosuppression was initiated. The time given in months indicates the length of time between karyotype timepoints.