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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Science. 2009 Mar 19;324(5928):801–804. doi: 10.1126/science.1171583

Fig. 3.

Fig. 3

Inhibition of decaprenylphosphoryl-β-d-ribose epimerization by BTZ. (A) Effect of different BTZ derivatives (table S1) on DPA production from DPR by using mycobacterial membranes in vitro. Lane 1, no drug control; lane 2, BTZ038; lane 3, BTZ043; lane 4, BTZ044; lane 5, BTZ045S; lane 6, BTZ045R. (B) Production of DPA from DPR requires both Rv3790 (DprE1) and Rv3791 (DprE2). E. coli strains that were used in the experiment (​26​) expressed the following M. tuberculosis proteins: lane 1, none; lane 2, Rv3790-Rv3791; lane 3, none; lane 4, Rv3791; lane 5, none; lane 6, Rv3790; lane 7, none; lane 8, Rv3790. (C) Effect of BTZ043 on DPA production by using cell wall fractions from BTZ-sensitive M. bovis BCG and its BTZ-resistant mutant, BN2 (Table 1).