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. 2011 Feb;178(2):525–536. doi: 10.1016/j.ajpath.2010.10.002

Figure 7.

Figure 7

EPHX2 and AR signaling. A: Western blot analysis of AR and PSA protein levels after siRNA-induced EPHX2 gene silencing. β-Actin was used as a loading control. Relative value for each blot is indicated; relative expression in control sample was set as 1. B: Combinatorial treatment of LNCaP cells with EPHX2 siRNA and flutamide. Cell viability of EPHX2 siRNA-treated cells is shown. Cell viability in the scrambled control sample was set as 100% in both treatments (no flutamide or 10 μmol/L flutamide). P values for individual treatments are given, compared with the scrambled control. P value for the difference in cell viability in EPHX2 siRNA treated samples after different treatments is also indicated. **P < 0.01, ***P < 0.001.