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. 2011 Feb;178(2):895–910. doi: 10.1016/j.ajpath.2010.10.001

Figure 8.

Figure 8

RHAMM and PKCα reduce stability of perinuclear microtubules. A, B: Confocal microscopic images of total α-tubulin (left panels) and acetylated tubulin (right panels). A: Control neointimal SMC has stable microtubules mainly in the cytoplasm close to the cell periphery. B: Neointimal SMC treated with siRNA for RHAMM has stable microtubules in the perinuclear region. Dashed line indicates the wound. C: PKC inhibitor BIM I treatment and siRNA for RHAMM reduce the dynamic microtubules, whereas siRNA for ARPC5 has no effect on dynamic microtubules. *P < 0.05. Error bars indicate ±SD. Scale bars = 10 μm.