| Selective serotonin reuptake inhibitors (SSRIs) |
| Citalopram (Celexa®) |
10 mg to 20 mg per day |
10 mg to 40 mg per day |
Nausea, vomiting, dry mouth, headache, somnolence, insomnia, increased sweating, tremor, diarrhea, sexual dysfunction |
| Escitalopram (Lexapro®) |
10 mg per day |
5 mg to 20 mg per day |
Suicidal behavior, fever, insomnia, dizziness, somnolence, paresthesia, light headedness, migraine, tremor, vertigo, abnormal dreams, irritability, fatigue, lethargy, palpitations, hypertension, flushing, chest pain, nausea, diarrhea, constipation, indigestion, vomiting, dry mouth, heartburn, flatulence, gastroesophageal reflux, ejaculation disorder, urinary frequency |
| Fluoxetine (Prozac®) |
10 mg per day |
5 mg to 40 mg per day |
Nausea, vomiting, diarrhea, insomnia, nervousness, restlessness, agitation, anxiety, light headedness, drowsiness, fatigue, headache, tremor, initial weight loss, possible long-term weight gain, hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH), increased risk of bleeding (upper gastrointestinal and intraoperative) with co-administration of nonsteroidal anti-inflammatory drugs, aspirin, and warfarin (Coumadin®). |
| Paroxetine (Paxil®, Paxil CR®) |
10 mg per day |
5 mg to 40 mg per day |
Headache, somnolence, dizziness, insomnia, dry mouth, constipation, diarrhea, ejaculatory disturbances, weakness, diaphoresis |
| Sertraline (Zoloft®) |
12.5 mg to 25 mg per day |
25 mg to 200 mg per day |
Insomnia, somnolence, dizziness, headache, fatigue, dry mouth, diarrhea, nausea, ejaculatory disturbances |
| Non-SSRIs |
| Buproprion (Wellbutrin®, Wellbutrin SR®, Wellbutrin XL®) |
37.5 mg to 75 mg per day; SR: 75 mg to 100 mg every morning; XL: 150 mg every morning |
150 mg in two to three divided dosages; SR: 100 mg twice per day; XL: 150 mg per day |
Dizziness, anxiety, agitation, dry mouth, insomnia, headache, nausea, constipation or diarrhea, tremor |
| Duloxetine (Cymbalta®) |
20 mg per day |
20 mg to 60 mg per day |
Nausea, dry mouth, constipation, poor appetite, diarrhea, headache, insomnia, somnolence, fatigue, diaphoresis, dizziness |
| Mirtazapine (Remeron®, Remeron SolTab®) |
7.5 mg at bedtime |
7.5 mg to 45 mg at bedtime |
Somnolence, increased appetite with weight gain, increased serum cholesterol, constipation, dry mouth |
| Venlafaxine (Effexor®, Effexor XR®) |
25 mg twice per day; XR: 37.5 mg per day |
150 mg per day in divided dosages; XR: 150 mg per day |
Headache, somnolence, dizziness, insomnia, nervousness, nausea, dry mouth, constipation, anorexia, abnormal ejaculation/orgasm, weakness, diaphoresis |
| Tricyclic antidepressant drugs |
| Desipramine (Norpramin®) |
25 mg per day |
100 mg per day |
Serotonin syndrome, anticoagulant effect with warfarin, cardiotoxicity, orthostasis, hypotension, hypertension, anticholinergic effects, tremor, agitation, insomnia |
| Nortriptyline (Pamelor®) |
10 mg to 25 mg per day |
50 mg per day |
Orthostasis, hypertension, myocardial infarction, ataxia, extrapyramidal symptoms, seizures, glucose dysregulation, SIADH, sexual dysfunction, dry mouth, anorexia, constipation, nausea, vomiting, diarrhea, weight gain/loss, urinary retention, impotence, blood dyscrasia, increased levels in liver function test values, paresthesia, mydriasis |
