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. 2011 Jul 1;22(13):2373–2383. doi: 10.1091/mbc.E10-12-0938

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© 2011 Andersen et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 3: — Dependence of Rev3 nuclear focus formation on other TLS polymerases following UV irradiation. (A) Rev3 nuclear focus formation is dependent on Rev1. In control immortalized fibroblasts (NF1604), UV-induced, NP40-resistant Rev3 nuclear foci colocalized with Rev1 foci (left). However, in genetically matched Rz20 cells in which Rev1 is depleted by a REV1-specific ribozyme, the Rev3 foci were not observed (right). (B) Rev3 nuclear focus formation is independent of Polη. In control normal fibroblasts (GM08402), UV-induced, NP40-resistant Rev3 nuclear foci colocalized with Polη foci (control, left). The Rev3 nuclear focus formation was not altered in an XPV cell line (GM03617) lacking endogenous Polη (right). (C, D) Statistical analyses of experimental results as shown in A and B, respectively.