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Increased sensitivity of GSNOR−/− mice to acute DEN toxicity. Kaplan–Meier survival curves of wild-type (WT, n = 23), GSNOR−/− (KO, n = 22), and iNOS−/−GSNOR−/− (DKO, n = 20) mice following intraperitoneal injection of DEN (37.5 μg/g). Survival of GSNOR−/− mice was significantly lower than that of wild-type (P < 0.002, log-rank test) or iNOS−/−GSNOR−/− (P < 0.006) mice.
