Table III.

Tagging SNPs for CNP992 and CNP2454 and their associations with PCa aggressiveness in JHH1, JHH2, CGEMS and CAPS populations

Marker	Variation	Population	Minor allele	Aggressive (minor allele copy number)			Nonaggressive (minor allele copy number)			MAF		OR(95%CI)a	Pa
				0	1	2	0	1	2	Aggressive	Nonaggressive
CNP992 (rs1547024)	Deletion (T > C)	JHH1 (n = 817)	DEL	104	205	93	136	196	83	0.486	0.436	1.22(1.01–1.48)	0.044
		JHH1 (n = 931)	C	119	218	104	159	235	96	0.483	0.436	1.21(1.01–1.45)	0.043
		Confirmation
		JHH2 (n = 1849)	C	268	450	209	279	446	197	0.468	0.456	1.05(0.93–1.19)	0.446
		CGEMS (n = 1136)	C	157	335	170	137	239	98	0.510	0.459	1.23(1.04–1.46)	0.016
		CAPS (n = 2796)	C	344	589	265	453	754	391	0.467	0.481	0.95(0.85–1.05)	0.323
		Subtotal										1.06(0.92–1.22)	0.435
		All populationb										1.09(0.96–1.23)	0.190
CNP2454 (rs2209313)	Deletion (C > T)	JHH1 (n = 817)	nonDELc	246	142	14	279	128	8	0.211	0.173	1.30(1.01–1.68)	0.045
		JHH1 (n = 938)	T	272	156	17	330	151	12	0.214	0.178	1.27(1.01–1.61)	0.045
		Confirmation
		JHH2 (n = 1896)	T	564	344	42	600	300	46	0.225	0.207	1.11(0.95–1.30)	0.177
		CGEMS (n = 1168)	T	400	252	29	309	159	19	0.228	0.202	1.17(0.95–1.44)	0.136
		CAPS (n = 2826)	T	768	385	62	1074	484	53	0.210	0.183	1.18(1.03–1.34)	0.014
		Subtotal										1.15(1.05–1.26)	1.77E-03
		All populationb										1.17(1.07–1.27)	2.75E-04

^aP-values and ORs were calculated by assuming a log-additive genetic model (1 d.f.).

^bP value and OR (95% CI) were derived from Mantel–Haenszel analysis.

^cAbsence of this segment was the minor allele for CNP2454.