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. 2011 Jul 1;6(7):e21783. doi: 10.1371/journal.pone.0021783

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Sato et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) Bar graphs showing the percentage of all neurons in saline- (Sal) and cocaine- (Coc) treated male (M) and female (F) rats that were FosB-IR at any intensity level (Total FosB), and broken down into medium or darkly stained cells. B) Bar graphs showing the proportion of FosB-IR cells in each anatomical zone of the dorsal striatum. Each bar shows the percentage of all neurons in each treatment group that were light, medium, or darkly stained. Overall FosB-IR was higher in the Medial and Ventral, relative to the Lateral, zone, while cocaine-induced increases were most prominent in the Lateral zone. Additionally, females exhibited slightly higher FosB-IR than males. C) The partitioning scheme used to define Medial (M), Intermediate (I), Lateral (L), and Ventral (V) zones. D) A table summarizing the statistically significant differences (p<0.05) for dorsal striatum as a whole (Overall) and each of the zones. “D” indicates a significant drug effect, and “S” indicates a significant sex difference (See text).