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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Mol Carcinog. 2011 Jan 25;50(9):655–667. doi: 10.1002/mc.20738

Figure 6.

Figure 6

CDODA-Me and CF3DODA-Me decrease PTTG-1 and PTTG-1-dependent responses. (A) Decreased luciferase activity. HTh-74 cells were transfected with pPTTG-1(−1371/+3)luc, treated with CDODA-Me or CF3DODA-Me, and luciferase activity was determined as described in the Materials and Methods. Results are expressed as means ± SE for three replicate experiments. Significantly (p < 0.05) decreased activity is indicated (*). Decreased expression of Myc protein in cells treated with CDODA-Me (B) or CF3DODA-Me (C). Thyroid cancer cells were treated with CDODA-Me or CF3DODA-Me for 24 hr, and whole cell lysates were analyzed for expression of Myc by western blots as outlined in the Materials and Methods. (D) Decreased expression of FGF2 mRNA levels. K-18 and HTh-74 cells were treated with CDODA-Me or CF3DODA-Me for 24 hr, and FGF2 mRNA levels were determined by RT-PCR as described in the Materials and Methods.