Table 3.
Adjusted Association between the Lymph Node Ratio and Survival of Patients with N1 Disease
| Variable | Lung Cancer-specific Survival Hazard Ratio (95% CI1) |
Overall Survival Hazard Ratio (95% CI) |
|---|---|---|
| Lymph Node Ratio | ||
| ≤0.15 | Reference | Reference |
| 0.16-0.5 | 1.28 (1.15-1.43) | 1.25 (1.14-1.38) |
| >0.5 | 1.96 (1.74-2.22) | 1.82 (1.63-2.03) |
| Age, years | 1.02 (1.00-1.04) | 1.02 (1.01-1.04) |
| Female | 0.87 (0.80-0.96) | 0.86 (0.79-0.93) |
| Race/Ethnicity | ||
| White | Reference | Reference |
| Black | 1.02 (0.88-1.18) | 1.11 (0.98-1.26) |
| Hispanic | 0.90 (0.71-1.16) | 1.00 (0.81-1.24) |
| Other | 0.87 (0.73-1.04) | 0.88 (0.74-1.03) |
| Married | 0.89 (0.81-0.97) | 0.84 (0.78-0.92) |
| Histology | ||
| Adenocarcinoma | Reference | Reference |
| Squamous cell carcinoma | 0.73 (0.65-0.82) | 0.81 (0.74-0.89) |
| Large cell carcinoma | 1.09 (0.91-1.31) | 1.12 (0.96-1.32) |
| Bronchioalveolar carcinoma | 0.85 (0.68-1.05) | 0.92 (0.76-1.11) |
| Other | 0.94 (0.78-1.15) | 0.91 (0.76-1.10) |
| Tumor Status | ||
| T1A | Reference | Reference |
| T1B | 1.31 (1.09-1.57) | 1.29 (1.10-1.52) |
| T2 | 1.34 (1.10-1.63) | 1.30 (1.09-1.55) |
| T2A | 1.38 (1.17-1.62) | 1.35 (1.17-1.56) |
| T2B | 1.67 (1.38-2.02) | 1.59 (1.34-1.88) |
| T3 | 1.91 (1.59-2.29) | 1.72 (1.46-2.02) |
| Tumor Location | ||
| Upper lobe | Reference | Reference |
| Middle lobe | 1.00 (0.80-1.25) | 0.98 (0.80-1.20) |
| Lower lobe | 1.20 (1.09-1.33) | 1.24 (1.13-1.35) |
| Other location | 1.06 (0.89-1.26) | 1.12 (0.96-1.31) |
| Type of surgery | ||
| Lobectomy | Reference | Reference |
| Pneumonectomy | 1.22 (1.09-1.37) | 1.20 (1.09-1.33) |
| Postoperative Radiation Therapy | 1.07 (0.97-1.17) | 1.05 (0.97-1.14) |