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. Author manuscript; available in PMC: 2012 Jul 15.
Published in final edited form as: Cancer. 2011 Jan 18;117(14):3163–3172. doi: 10.1002/cncr.25891

Figure 3.

Figure 3

Representative cytotoxicity experiments (Effector to target: E/T; 25:1 and 50:1) using hRS7 against high Trop-2 expressing [i.e., USPC ARK-2 (upper panel), USPC ARK-3 (middle panel)] and low Trop-2 expressing USPC cell lines [i.e., USPC ARK-1 (lower panel)]. High levels of hRS7 induced cytotoxicity were evident against USPC ARK-2 and USPC ARK-3 primary cell lines expressing high levels of Trop-2. In contrast, negligible cytotoxicity was detectable against USPC ARK-1 (i.e., a low Trop-2 expressor cell line). In all cell lines tested, no significant cytotoxicity was detected in the absence of hRS7 or in the presence of Rituximab control mAb.