Table 5.
A selected list of glycated peptides identified from spectrin that show up-regulation in AGT vs NGT erythrocytes
| Gene Symbol | IPI No | Protein Name | Glycation Site | Peptide Sequence | Peptide Count AGT | Peptide Count NGT |
|---|---|---|---|---|---|---|
| SPTA1 | IPI:IPI00220741.6 | spectrin alpha chain | 210 | K.FEDFQVELVAK#EGR.V | 7 | 4 |
| 210 | K.KFEDFQVELVAK#EGR.V | 50 | 22 | |||
| 281 | R.DVTEAIQWIK#EK.E | 14 | 9 | |||
| 319 | R.NLAVMSDK#VK.E | 8 | 3 | |||
| 579 | R.RLLK#ESLLLQK.L | 4 | 1 | |||
| 595 | K.LYEDSDDLK#NWINK.K | 5 | 2 | |||
| 779 | R.FEALK#EPLATR.K | 6 | 3 | |||
| 940 | K.K#HEAFLLDLNSFGDSM* K.A | 8 | 3 | |||
| 1102 | K.K#AENTGVELDDVWELQK.K | 21 | 12 | |||
| 1468 | K.ITDLEHFAESLIADEHYAK#EEIATR.L | 9 | 7 | |||
| 1486 | K.ALK#AQLIDER.T | 29 | 15 | |||
| 1992 | R.LPEITDLK#DK.L | 30 | 5 | |||
| 2132 | R.TWK#HLSDIIEER.E | 10 | 6 | |||
|
| ||||||
| SPTB | IPI:IPI00216704.8 | Spectrin beta chain | 79 | R.ITDLYK#DLR.D | 6 | 4 |
| 291 | R.VGK#VIDHAIETEK.M | 6 | 2 | |||
| 354 | R.TVEKPPK#FQEK.G | 3 | NA | |||
| 568 | K.HLLEVEDLLQK#HK.L | 5 | NA | |||
| 640 | R.LWK#FFWEM* DEAESWIK.E | 5 | NA | |||
| 653 | K.FFWEM* DEAESWIK#EK.E | 6 | 2 | |||
| 653 | K.FFWEMDEAESWIK#EK.E | 7 | 2 | |||
| 728 | K.EVSAQWDQLK#DLAAFCK.K | 6 | 3 | |||
| 728 | R.IKEVSAQWDQLK#DLAAFCK.K | 18 | 5 | |||
| 1174 | R.SHTLAQCLGFQEFQK#DAK.Q | 3 | NA | |||
| 1675 | R.LQGQVDKHYAGLK#DVAEER.K | 12 | 9 | |||
| 1684 | K.RK#LENM* YHLFQLK.R | 3 | NA | |||
| 1684 | K.RK#LENMYHLFQLK.R | 3 | NA | |||
| 1684 | R.K#LENM* YHLFQLK.R | 9 | 3 | |||
| 1684 | R.K#LENMYHLFQLK.R | 12 | 7 | |||
| 1695 | K.LENM* YHLFQLK#R.E | 9 | 7 | |||
| 1695 | K.LENMYHLFQLK#R.E | 7 | 4 | |||
| 1695 | K.RKLENM* YHLFQLK#R.E | 15 | 4 | |||
| 1695 | R.KLENM* YHLFQLK#R.E | 69 | 39 | |||
| 1695 | R.KLENMYHLFQLK#R.E | 26 | 13 | |||
| 1815 | R.YFYTGAEILGLIDEK#HR.E | 37 | 32 | |||
| 1869 | R.LQTAYAGEK#AEAIQNK.E | 10 | 8 | |||
| 1876 | K.AEAIQNK#EQEVSAAWQALLDACAGR.R | 35 | 19 | |||
| 1996 | R.RKEMNEK#WEAR.W | 4 | 1 | |||
*
and # in peptide sequence represent oxidized methionine and Amadori compound modification, respectively. NA = not observed