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. Author manuscript; available in PMC: 2012 Jul 15.
Published in final edited form as: Bioorg Med Chem Lett. 2011 May 30;21(14):4238–4242. doi: 10.1016/j.bmcl.2011.05.078

Figure 1.

Figure 1

Kinetic analysis of C21 mediated SHP2 inhibition showed a competitive inhibition mode. The concentrations of C21 were 0 (●), 4 (○), 8 (▼) and 12 µM (▽) respectively.