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. Author manuscript; available in PMC: 2012 Jul 15.
Published in final edited form as: Bioorg Med Chem Lett. 2011 May 30;21(14):4238–4242. doi: 10.1016/j.bmcl.2011.05.078

Table 1.

Structures and IC50 values of C18, C21, C30, and four analogues of C21 against SHP2.

Compd. Structure IC50 (µM)
C18 graphic file with name nihms300889t1.jpg 181 ± 12
C30 graphic file with name nihms300889t2.jpg 176 ± 11
C21 graphic file with name nihms300889t3.jpg 8.3 ± 0.1
C21-A1 graphic file with name nihms300889t4.jpg 41 ± 1
C21-A2 graphic file with name nihms300889t5.jpg 155 ± 6
C21-A3 graphic file with name nihms300889t6.jpg NDa
C21-A4 graphic file with name nihms300889t7.jpg NDa
a

No detectable inhibition at 1,000 µM